Find Your Metabolic 
Balance Match

Two Approaches to Insulin Resistance During Menopause

Insulin resistance increases significantly during menopause, contributing to weight gain and difficulty losing weight. Two compounds have drawn attention for addressing this: metformin (a prescription medication) and berberine (a natural compound found in several plants). Understanding how they compare helps women make informed decisions with their healthcare providers.

Metformin is an FDA-approved medication originally developed for Type 2 diabetes. It works primarily by reducing liver glucose production and improving insulin sensitivity. Some physicians prescribe it off-label for menopause-related weight management. A 2024 review noted growing interest in metformin's potential anti-aging and metabolic benefits beyond diabetes management.

Oneleaf Health, '7 Essential Supplements for Menopause Belly Fat,' reviewed by board-certified physicians, 2026.